A Chemically Defined Synthetic Cell Capable of Growth and Replication

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  • old dog
    Patriot Hero
    • Nov 2024
    • 3288

    #1

    A Chemically Defined Synthetic Cell Capable of Growth and Replication

    It's called the Spud Cell. Even the developer is reluctant to call it "alive" but it's damn close. Biology is not my strong suit, hope to get informed comments on this discovery.

    “Life is not binary,” said Kate Adamala, a synthetic biologist who led the research. “That’s why I’m hesitant to call this ‘alive.’ There’s no clear line, as much as we would love it to be.”
    https://www.nytimes.com/interactive/...smid=url-share


    Prof. Kate Adamala and her team at the University of Minnesota have built SpudCell, a cell-like system constructed entirely from known chemical components that can perform a complete cell cycle.

    The system contains 36 purified enzymes, a 90,000 base pair genome spread across nine separate DNA molecules, and a lipid membrane. SpudCell is able to grow, replicate its genome, divide, and undergo selection and competition across multiple generations.

    Unlike earlier work on minimal cells that carved down living cells, SpudCell is built entirely bottom-up from individually purified, non-living components. It is the first time such a system has demonstrated a complete cell cycle.
    SpudCell and Biotic — announcement and media factsheet.
    If there are no dogs in Heaven, then when I die I want to go where they went. - Will Rodgers
  • Billy_Bob
    Systems Administrator
    • Sep 2022
    • 8196

    #2
    Hmmmmmmm....

    Very interesting! Going to have to look at this thing fairly close. Don't know much about them but it sounds interesting. I still have that "what could possibly go wrong" feeling.
    "Those who would give up essential liberty to purchase a little temporary safety deserve neither liberty nor safety."
    *Benjamin Franklin, Historical Review of Pennsylvania, 1759

    E-Mail; systemadmin@patriotaction.us

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    • PassingLane
      Patriot Master
      • Mar 2026
      • 411

      #3
      These researchers frequently like to make their work sound more advanced than it really is in order to secure more funding.

      Comment

      • old dog
        Patriot Hero
        • Nov 2024
        • 3288

        #4
        Originally posted by PassingLane
        These researchers frequently like to make their work sound more advanced than it really is in order to secure more funding.
        Yeah, 190 page technical preprint and I can barely grok the one paragraph abstract. Just released July 2nd, awaiting peer review as if that means anything in today's world ... they'll probably have AI do ti. Anyway, it sounds like there is some there there and the researcher is not claiming it's "alive" as she thinks the term us not well defined. On the whole, I put more credibility to papers based on actual experiments rather than theoretical speculation. I'm sure there will be lots of 3rd party analysis soon.
        If there are no dogs in Heaven, then when I die I want to go where they went. - Will Rodgers

        Comment

        • PassingLane
          Patriot Master
          • Mar 2026
          • 411

          #5
          Originally posted by old dog

          Yeah, 190 page technical preprint and I can barely grok the one paragraph abstract. Just released July 2nd, awaiting peer review as if that means anything in today's world ... they'll probably have AI do ti. Anyway, it sounds like there is some there there and the researcher is not claiming it's "alive" as she thinks the term us not well defined.
          A biological system that can reproduce itself is alive to me.

          Comment

          • old dog
            Patriot Hero
            • Nov 2024
            • 3288

            #6
            Originally posted by PassingLane

            A biological system that can reproduce itself is alive to me.
            There's something about it requiring "external stimulus" to reproduce. Porn for microbes?
            If there are no dogs in Heaven, then when I die I want to go where they went. - Will Rodgers

            Comment

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